Molecular Evolution and Structural Features of IRAK Family Members
نویسندگان
چکیده
منابع مشابه
Molecular Evolution and Structural Features of IRAK Family Members
The interleukin-1 receptor-associated kinase (IRAK) family comprises critical signaling mediators of the TLR/IL-1R signaling pathways. IRAKs are Ser/Thr kinases. There are 4 members in the vertebrate genome (IRAK1, IRAK2, IRAKM, and IRAK4) and an IRAK homolog, Pelle, in insects. IRAK family members are highly conserved in vertebrates, but the evolutionary relationship between IRAKs in vertebrat...
متن کاملIRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Toll/IL-1 receptor family members are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is Ser/Thr kinases, which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol. The fruit fly Drosophila melanogaster has one member of this family of kinases, termed Pelle...
متن کاملEvolutionary, Structural and Functional Interplay of the IκB Family Members
A primary level of control for nuclear factor kappa B (NF-κB) is effected through its interactions with the inhibitor protein, inhibitor of kappa B (IκB). Several lines of evidence confirm the existence of multiple forms of IκB that appear to regulate NF-κB by distinct mechanisms. Therefore, we performed a comprehensive bioinformatics analysis to understand the evolutionary history and intrinsi...
متن کاملMolecular evolution of alcohol dehydrogenase 1 in members of the grass family.
The molecular evolution of the alcohol dehydrogenase 1 (Adh1; alcohol:NAD+ oxidoreductase, EC 1.1.1.1) locus in members of the grass family is analyzed. We report the complete DNA sequence of a genomic clone of Adh1 from Pennisetum glaucum cv. Tift 23DB (pearl millet). The gene is characterized by ten exons and nine introns. The 5' flanking region of the gene contains sequences corresponding to...
متن کاملConfiguring Members of a Family of Requirements Using Features
We explicitly consider entire families of software requirements; this enables us to configure family members using features. Our goal is to avoid feature interaction problems by a software engineering approach. Naive feature orientation does not scale due to complexity problems. But we can structure a family of requirements into requirements modules to make it easier to maintain. We then can co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0049771